Deletion of interleukin-6 alleviated interstitial fibrosis in streptozotocin-induced diabetic cardiomyopathy of mice through affecting TGFβ1 and miR-29 pathways

Interleukin 6 (IL-6) has been shown to be an important regulator of cardiac interstitial fibrosis. In this study, we explored the role of interleukin-6 in the development of diabetic cardiomyopathy and the underlying mechanisms. Cardiac function of IL-6 knockout mice was significantly improved and i...

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Detalles Bibliográficos
Autores principales: Zhang, Yang, Wang, Jing-Hao, Zhang, Yi-Yuan, Wang, Ying-Zhe, Wang, Jin, Zhao, Yue, Jin, Xue-Xin, Xue, Gen-Long, Li, Peng-Hui, Sun, Yi-Lin, Huang, Qi-He, Song, Xiao-Tong, Zhang, Zhi-Ren, Gao, Xu, Yang, Bao-Feng, Du, Zhi-Min, Pan, Zhen-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789642/
https://www.ncbi.nlm.nih.gov/pubmed/26972749
http://dx.doi.org/10.1038/srep23010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789642/
https://www.ncbi.nlm.nih.gov/pubmed/26972749
http://dx.doi.org/10.1038/srep23010

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