Targeted deletion of Atg5 in chondrocytes promotes age-related osteoarthritis

OBJECTIVES: It has been suggested that the lysosomal recycling process called macro-autophagy plays a role in osteoarthritis development. We thus decided to genetically ablate the autophagy-indispensable Atg5 gene specifically in chondrocytes and analyse the development of osteoarthritis upon aging...

Descripción completa

Detalles Bibliográficos
Autores principales: Bouderlique, Thibault, Vuppalapati, Karuna K, Newton, Phillip T, Li, Lei, Barenius, Björn, Chagin, Andrei S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2016
Materias:
Basic and Translational Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789686/
https://www.ncbi.nlm.nih.gov/pubmed/26438374
http://dx.doi.org/10.1136/annrheumdis-2015-207742

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789686/
https://www.ncbi.nlm.nih.gov/pubmed/26438374
http://dx.doi.org/10.1136/annrheumdis-2015-207742

Ejemplares similares