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Targeted deletion of Atg5 in chondrocytes promotes age-related osteoarthritis

OBJECTIVES: It has been suggested that the lysosomal recycling process called macro-autophagy plays a role in osteoarthritis development. We thus decided to genetically ablate the autophagy-indispensable Atg5 gene specifically in chondrocytes and analyse the development of osteoarthritis upon aging...

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Detalles Bibliográficos
Autores principales:	Bouderlique, Thibault, Vuppalapati, Karuna K, Newton, Phillip T, Li, Lei, Barenius, Björn, Chagin, Andrei S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2016
Materias:	Basic and Translational Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789686/ https://www.ncbi.nlm.nih.gov/pubmed/26438374 http://dx.doi.org/10.1136/annrheumdis-2015-207742

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