Hypoxia-induced nitric oxide production and tumour perfusion is inhibited by pegylated arginine deiminase (ADI-PEG20)

The hypoxic tumour microenvironment represents an aggressive, therapy-resistant compartment. As arginine is required for specific hypoxia-induced processes, we hypothesised that arginine-deprivation therapy may be useful in targeting hypoxic cancer cells. We explored the effects of the arginine-degr...

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Detalles Bibliográficos
Autores principales: Burrows, Natalie, Cane, Gaelle, Robson, Mathew, Gaude, Edoardo, J. Howat, William, Szlosarek, Peter W., Pedley, R. Barbara, Frezza, Christian, Ashcroft, Margaret, Maxwell, Patrick H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789736/
https://www.ncbi.nlm.nih.gov/pubmed/26972697
http://dx.doi.org/10.1038/srep22950

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789736/
https://www.ncbi.nlm.nih.gov/pubmed/26972697
http://dx.doi.org/10.1038/srep22950

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