Celastrol inhibits prostaglandin E2-induced proliferation and osteogenic differentiation of fibroblasts isolated from ankylosing spondylitis hip tissues in vitro

BACKGROUND: Heterotopic ossification on the enthesis, which develops after subsequent inflammation, is one of the most distinctive features in ankylosing spondylitis (AS). Prostaglandin E2 (PGE-2) serves as a key mediator of inflammation and bone remodeling in AS. Celastrol, a well-known Chinese med...

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Detalles Bibliográficos
Autores principales: Zou, Yu-Cong, Yang, Xian-Wen, Yuan, Shi-Guo, Zhang, Pei, Li, Yi-Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4790082/
https://www.ncbi.nlm.nih.gov/pubmed/27022241
http://dx.doi.org/10.2147/DDDT.S97463

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4790082/
https://www.ncbi.nlm.nih.gov/pubmed/27022241
http://dx.doi.org/10.2147/DDDT.S97463

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