IL-1 signaling modulates STAT activation to antagonize retinoic acid signaling and control Th17–iTreg balance

Interleukin 17 (IL-17)-producing helper (T(H)17) and inducible regulatory CD4(+) T (iT(reg)) cells emerge from an overlapping developmental program. In the intestines, the vitamin A metabolite retinoic acid (RA) is produced at steady state and acts as an important cofactor to induce iT(reg) cell dev...

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Detalles Bibliográficos
Autores principales: Basu, Rajatava, Whitley, Sarah K., Bhaumik, Suniti, Zindl, Carlene L., Schoeb, Trenton R., Benveniste, Etty N., Pear, Warren S., Hatton, Robin D., Weaver, Casey T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4790724/
https://www.ncbi.nlm.nih.gov/pubmed/25642823
http://dx.doi.org/10.1038/ni.3099

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4790724/
https://www.ncbi.nlm.nih.gov/pubmed/25642823
http://dx.doi.org/10.1038/ni.3099

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