Oridonin Attenuates Synaptic Loss and Cognitive Deficits in an Aβ(1–42)-Induced Mouse Model of Alzheimer’s Disease

Synaptic loss induced by beta-amyloid (Aβ) plays a critical role in the pathophysiology of Alzheimer’s disease (AD), but the mechanisms underlying this process remain unknown. In this study, we found that oridonin (Ori) rescued synaptic loss induced by Aβ(1–42) in vivo and in vitro and attenuated th...

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Detalles Bibliográficos
Autores principales: Wang, Sulei, Yu, Linjie, Yang, Hui, Li, Chaosheng, Hui, Zhen, Xu, Yun, Zhu, Xiaolei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4790895/
https://www.ncbi.nlm.nih.gov/pubmed/26974541
http://dx.doi.org/10.1371/journal.pone.0151397

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4790895/
https://www.ncbi.nlm.nih.gov/pubmed/26974541
http://dx.doi.org/10.1371/journal.pone.0151397

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