Amino-Terminal Fusion of Epidermal Growth Factor 4,5,6 Domains of Human Thrombomodulin on Streptokinase Confers Anti-Reocclusion Characteristics along with Plasmin-Mediated Clot Specificity

Streptokinase (SK) is a potent clot dissolver but lacks fibrin clot specificity as it activates human plasminogen (HPG) into human plasmin (HPN) throughout the system leading to increased risk of bleeding. Another major drawback associated with all thrombolytics, including tissue plasminogen activat...

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Detalles Bibliográficos
Autores principales: Maheshwari, Neeraj, Kantipudi, Satish, Maheshwari, Anand, Arora, Kashika, Vandana, Kwatra, Neha, Sahni, Girish
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4790962/
https://www.ncbi.nlm.nih.gov/pubmed/26974970
http://dx.doi.org/10.1371/journal.pone.0150315

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4790962/
https://www.ncbi.nlm.nih.gov/pubmed/26974970
http://dx.doi.org/10.1371/journal.pone.0150315

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