Intrinsically active variants of Erk oncogenically transform cells and disclose unexpected autophosphorylation capability that is independent of TEY phosphorylation

The receptor-tyrosine kinase (RTK)/Ras/Raf pathway is an essential cascade for mediating growth factor signaling. It is abnormally overactive in almost all human cancers. The downstream targets of the pathway are members of the extracellular regulated kinases (Erk1/2) family, suggesting that this fa...

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Detalles Bibliográficos
Autores principales: Smorodinsky-Atias, Karina, Goshen-Lago, Tal, Goldberg-Carp, Anat, Melamed, Dganit, Shir, Alexei, Mooshayef, Navit, Beenstock, Jonah, Karamansha, Yael, Darlyuk-Saadon, Ilona, Livnah, Oded, Ahn, Natalie G., Admon, Arie, Engelberg, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791124/
https://www.ncbi.nlm.nih.gov/pubmed/26658610
http://dx.doi.org/10.1091/mbc.E15-07-0521

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791124/
https://www.ncbi.nlm.nih.gov/pubmed/26658610
http://dx.doi.org/10.1091/mbc.E15-07-0521

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