Targeting colorectal cancer via its microenvironment by inhibiting IGF-1 Receptor-insulin receptor substrate and STAT3 signaling

The tumor microenvironment (TME) exerts critical pro-tumorigenic effects through cytokines and growth factors that support cancer cell proliferation, survival, motility and invasion. Insulin-like growth factor-1 (IGF-1) and Signal transducer and activator of transcription 3 (STAT3) stimulate colorec...

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Detalles Bibliográficos
Autores principales: Sanchez-Lopez, Elsa, Flashner-Abramson, Efrat, Shalapour, Shabnam, Zhong, Zhenyu, Taniguchi, Koji, Levitzki, Alexander, Karin, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791217/
https://www.ncbi.nlm.nih.gov/pubmed/26364612
http://dx.doi.org/10.1038/onc.2015.326

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791217/
https://www.ncbi.nlm.nih.gov/pubmed/26364612
http://dx.doi.org/10.1038/onc.2015.326

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