p21-activated kinase group II small compound inhibitor GNE-2861 perturbs estrogen receptor alpha signaling and restores tamoxifen-sensitivity in breast cancer cells

Estrogen receptor alpha (ERα) is highly expressed in most breast cancers. Consequently, ERα modulators, such as tamoxifen, are successful in breast cancer treatment, although tamoxifen resistance is commonly observed. While tamoxifen resistance may be caused by altered ERα signaling, the molecular m...

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Detalles Bibliográficos
Autores principales: Zhuang, Ting, Zhu, Jian, Li, Zhilun, Lorent, Julie, Zhao, Chunyan, Dahlman-Wright, Karin, Strömblad, Staffan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791272/
https://www.ncbi.nlm.nih.gov/pubmed/26554417

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791272/
https://www.ncbi.nlm.nih.gov/pubmed/26554417

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