Computational analysis of the MCoTI-II plant defence knottin reveals a novel intermediate conformation that facilitates trypsin binding

MCoTI-I and II are plant defence proteins, potent trypsin inhibitors from the bitter gourd Momordica cochinchinensis. They are members of the Knottin Family, which display exceptional stability due to unique topology comprising three interlocked disulfide bridges. Knottins show promise as scaffolds...

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Detalles Bibliográficos
Autores principales: Jones, Peter M., George, Anthony M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791599/
https://www.ncbi.nlm.nih.gov/pubmed/26975976
http://dx.doi.org/10.1038/srep23174

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791599/
https://www.ncbi.nlm.nih.gov/pubmed/26975976
http://dx.doi.org/10.1038/srep23174

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