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Beneficial effect of xylose consumption on postprandial hyperglycemia in Korean: a randomized double-blind, crossover design
BACKGROUND: Previous studies have reported that xylose selectively inhibited the activity of sucrase. Xylose supplementation may have a beneficial effect on the postprandial glycemic response. However, no studies have investigated patients with IFG or the effectivity of a dose of D-xylose less than...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791768/ https://www.ncbi.nlm.nih.gov/pubmed/26979433 http://dx.doi.org/10.1186/s13063-016-1261-0 |
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author | Jun, Yun Ju Lee, Jinhee Hwang, Sehee Kwak, Jung Hyun Ahn, Hyeon Yeong Bak, Youn Kyung Koh, Jihoon Lee, Jong Ho |
author_facet | Jun, Yun Ju Lee, Jinhee Hwang, Sehee Kwak, Jung Hyun Ahn, Hyeon Yeong Bak, Youn Kyung Koh, Jihoon Lee, Jong Ho |
author_sort | Jun, Yun Ju |
collection | PubMed |
description | BACKGROUND: Previous studies have reported that xylose selectively inhibited the activity of sucrase. Xylose supplementation may have a beneficial effect on the postprandial glycemic response. However, no studies have investigated patients with IFG or the effectivity of a dose of D-xylose less than 10 % (w/w). METHODS: The present study determined the effect of xylose consumption on postprandial hyperglycemia in normal (n = 25) and hyperglycemic subjects (n = 50). Subjects in this double-blind crossover design study were randomly assigned to consume a sucrose drink (Control, sucrose 50 g + deionized water 100 g) or a sucrose drink additionally containing 5 g (Test 1, sucrose:xylose = 10:1), 3.33 g (Test 2, sucrose:xylose = 15:1), or 2.5 g (Test 3, sucrose:xylose = 20:1) of D-xylose separated by a one-week interval. RESULTS: Normal subjects in all test groups exhibited a significant decrease in serum glucose levels 15 min and 30 min after consuming the xylose-containing drinks compared to the control group. Significantly lower serum levels of insulin were observed at 15 min and 30 min after consuming the xylose-containing drinks compared to the control group. The test 1 group also exhibited a significantly lower insulin area under the curve than the control group. Hyperglycemic subjects (n = 50) in all test groups exhibited a significant decrease in serum glucose levels at 30 min compared to the control group. However, the test 1 group exhibited a significant increase in serum glucose levels at 120 min compared to the control group. Glucose-related markers did not significantly differ in each group. CONCLUSION: Xylose supplementation may exert a beneficial effect on postprandial glycemic responses in subjects with normal glucose levels and prediabetes. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT02654301. Registered 12 January 2016. |
format | Online Article Text |
id | pubmed-4791768 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-47917682016-03-16 Beneficial effect of xylose consumption on postprandial hyperglycemia in Korean: a randomized double-blind, crossover design Jun, Yun Ju Lee, Jinhee Hwang, Sehee Kwak, Jung Hyun Ahn, Hyeon Yeong Bak, Youn Kyung Koh, Jihoon Lee, Jong Ho Trials Research BACKGROUND: Previous studies have reported that xylose selectively inhibited the activity of sucrase. Xylose supplementation may have a beneficial effect on the postprandial glycemic response. However, no studies have investigated patients with IFG or the effectivity of a dose of D-xylose less than 10 % (w/w). METHODS: The present study determined the effect of xylose consumption on postprandial hyperglycemia in normal (n = 25) and hyperglycemic subjects (n = 50). Subjects in this double-blind crossover design study were randomly assigned to consume a sucrose drink (Control, sucrose 50 g + deionized water 100 g) or a sucrose drink additionally containing 5 g (Test 1, sucrose:xylose = 10:1), 3.33 g (Test 2, sucrose:xylose = 15:1), or 2.5 g (Test 3, sucrose:xylose = 20:1) of D-xylose separated by a one-week interval. RESULTS: Normal subjects in all test groups exhibited a significant decrease in serum glucose levels 15 min and 30 min after consuming the xylose-containing drinks compared to the control group. Significantly lower serum levels of insulin were observed at 15 min and 30 min after consuming the xylose-containing drinks compared to the control group. The test 1 group also exhibited a significantly lower insulin area under the curve than the control group. Hyperglycemic subjects (n = 50) in all test groups exhibited a significant decrease in serum glucose levels at 30 min compared to the control group. However, the test 1 group exhibited a significant increase in serum glucose levels at 120 min compared to the control group. Glucose-related markers did not significantly differ in each group. CONCLUSION: Xylose supplementation may exert a beneficial effect on postprandial glycemic responses in subjects with normal glucose levels and prediabetes. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT02654301. Registered 12 January 2016. BioMed Central 2016-03-15 /pmc/articles/PMC4791768/ /pubmed/26979433 http://dx.doi.org/10.1186/s13063-016-1261-0 Text en © Jun et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Jun, Yun Ju Lee, Jinhee Hwang, Sehee Kwak, Jung Hyun Ahn, Hyeon Yeong Bak, Youn Kyung Koh, Jihoon Lee, Jong Ho Beneficial effect of xylose consumption on postprandial hyperglycemia in Korean: a randomized double-blind, crossover design |
title | Beneficial effect of xylose consumption on postprandial hyperglycemia in Korean: a randomized double-blind, crossover design |
title_full | Beneficial effect of xylose consumption on postprandial hyperglycemia in Korean: a randomized double-blind, crossover design |
title_fullStr | Beneficial effect of xylose consumption on postprandial hyperglycemia in Korean: a randomized double-blind, crossover design |
title_full_unstemmed | Beneficial effect of xylose consumption on postprandial hyperglycemia in Korean: a randomized double-blind, crossover design |
title_short | Beneficial effect of xylose consumption on postprandial hyperglycemia in Korean: a randomized double-blind, crossover design |
title_sort | beneficial effect of xylose consumption on postprandial hyperglycemia in korean: a randomized double-blind, crossover design |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791768/ https://www.ncbi.nlm.nih.gov/pubmed/26979433 http://dx.doi.org/10.1186/s13063-016-1261-0 |
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