Cargando…

Yeast-based assays for screening 11β-HSD1 inhibitors

BACKGROUND: Intracellular metabolism of glucocorticoid hormones plays an important role in the pathogenesis of metabolic syndrome and regulates, among many physiological processes, collagen metabolism in skin. At the peripheral level the concentration of active glucocorticoids is mainly regulated by...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vanella, Rosario, Callari, Roberta, Weston, Anna, Heider, Harald, Schwab, Markus S., Kübler, Eric
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791775/ https://www.ncbi.nlm.nih.gov/pubmed/26980090 http://dx.doi.org/10.1186/s12934-016-0450-6

Ejemplares similares

Production of Putative Diterpene Carboxylic Acid Intermediates of Triptolide in Yeast
por: Forman, Victor, et al.
Publicado: (2017)

11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) Inhibitors Still Improve Metabolic Phenotype in Male 11β-HSD1 Knockout Mice Suggesting Off-Target Mechanisms
por: Harno, Erika, et al.
Publicado: (2013)

11β-HSD Types 1 and 2 in the Songbird Brain
por: Rensel, Michelle A., et al.
Publicado: (2018)

Novel small molecule 11β-HSD1 inhibitor from the endophytic fungus Penicillium commune
por: Sun, Weiguang, et al.
Publicado: (2016)

16-nor Limonoids from Harrisonia perforata as promising selective 11β-HSD1 inhibitors
por: Yan, Xiao-Hui, et al.
Publicado: (2016)

Macrophage 11β-HSD-1 deficiency promotes inflammatory angiogenesis
por: Zhang, Zhenguang, et al.
Publicado: (2017)

11β-HSD as a New Target in Pharmacotherapy of Metabolic Diseases
por: Kupczyk, Daria, et al.
Publicado: (2022)

TNFα-mediated Hsd11b1 binding of NF-κB p65 is associated with suppression of 11β-HSD1 in muscle
por: Doig, Craig L, et al.
Publicado: (2014)

Synthesis of Novel 2-(Isopropylamino)thiazol-4(5H)-one Derivatives and Their Inhibitory Activity of 11β-HSD1 and 11β-HSD2 in Aspect of Carcinogenesis Prevention
por: Kupczyk, Daria, et al.
Publicado: (2020)

Biosynthesis of angelyl-CoA in Saccharomyces cerevisiae
por: Callari, Roberta, et al.
Publicado: (2018)

Dynamic Control of ERG20 and ERG9 Expression for Improved Casbene Production in Saccharomyces cerevisiae
por: Callari, Roberta, et al.
Publicado: (2018)

Effect of 11β-HSD1 inhibitor on bone microstructure and bone density in rats with femoral head necrosis
por: Li, Feng, et al.
Publicado: (2020)

Multiplexed on-yeast serological assay for immune escape screening of SARS-CoV-2 variants
por: Lopez-Morales, Joanan, et al.
Publicado: (2023)

Getting to the heart of intracellular glucocorticoid regeneration: 11β-HSD1 in the myocardium
por: Gray, Gillian A, et al.
Publicado: (2016)

Glucocorticoids and 11β-HSD1 are major regulators of intramyocellular protein metabolism
por: Morgan, Stuart A, et al.
Publicado: (2016)

Inhibition of 11β-HSD1 by Tetracyclic Triterpenoids from Euphorbia kansui
por: Guo, Jie, et al.
Publicado: (2012)

Does the Caesarean Section Impact on 11β HSD2 and Fetal Cortisol?
por: Słabuszewska-Jóżwiak, Aneta, et al.
Publicado: (2020)

Equisetin is an anti-obesity candidate through targeting 11β-HSD1
por: Xu, Zhenlu, et al.
Publicado: (2022)

Effect of Glucocorticoid and 11β-Hydroxysteroid-Dehydrogenase Type 1 (11β-HSD1) in Neurological and Psychiatric Disorders
por: Dodd, Seetal, et al.
Publicado: (2022)

Selection and early clinical evaluation of the brain‐penetrant 11β‐hydroxysteroid dehydrogenase type 1 (11β‐HSD1) inhibitor UE2343 (Xanamem™)
por: Webster, Scott P, et al.
Publicado: (2017)

Effect of AZD4017, a Selective 11β-HSD1 Inhibitor, on Bone Turnover Markers in Postmenopausal Osteopenia
por: Abbas, Afroze, et al.
Publicado: (2022)

Intrahippocampal glucocorticoids generated by 11β-HSD1 affect memory in aged mice
por: Yau, Joyce L.W., et al.
Publicado: (2015)

Increased systemic and adipose 11β-HSD1 activity in idiopathic intracranial hypertension
por: Westgate, Connar S J, et al.
Publicado: (2022)

11β-HSD1 contributes to age-related metabolic decline in male mice
por: Morgan, Stuart A, et al.
Publicado: (2022)

Detection of Urinary Exosomal HSD11B2 mRNA Expression: A Useful Novel Tool for the Diagnostic Approach of Dysfunctional 11β-HSD2-Related Hypertension
por: De Santis, Domenica, et al.
Publicado: (2021)

Role of 11β-HSD type 1 in abnormal HPA axis activity during immune-mediated arthritis
por: Sattler, Janko, et al.
Publicado: (2018)

11β-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice
por: Hermanowski-Vosatka, Anne, et al.
Publicado: (2005)

Inhibition of 11β-HSD1 Expression by Insulin in Skin: Impact for Diabetic Wound Healing
por: Brazel, Christina B., et al.
Publicado: (2020)

11β-HSD1 participates in epileptogenesis and the associated cognitive impairment by inhibiting apoptosis in mice
por: Li, Xueying, et al.
Publicado: (2022)

11β-Hydroxysteroid Dehydrogenase Type 1(11β-HSD1) mediates insulin resistance through JNK activation in adipocytes
por: Peng, Kesong, et al.
Publicado: (2016)

Forebrain‐Specific Transgene Rescue of 11β‐HSD1 Associates with Impaired Spatial Memory and Reduced Hippocampal Brain‐Derived Neurotrophic Factor mRNA Levels in Aged 11β‐HSD1 Deficient Mice
por: Caughey, S., et al.
Publicado: (2017)

Variants of 11β-hydroxysteroid dehydrogenase (HSD11B) gene type 1 and 2 in Chinese obese adolescents
por: Chun, Zou Chao
Publicado: (2013)

Antifibrotic Effect of a Novel Selective 11β-HSD2 Inhibitor (WZ51) in a rat Model of Myocardial Fibrosis
por: Zhuang, Fei, et al.
Publicado: (2021)

Structural Insights and Docking Analysis of Adamantane-Linked 1,2,4-Triazole Derivatives as Potential 11β-HSD1 Inhibitors
por: Osman, Doaa A., et al.
Publicado: (2021)

11β-HSD1 Inhibitor Alleviates Non-Alcoholic Fatty Liver Disease by Activating the AMPK/SIRT1 Signaling Pathway
por: Chen, Ying, et al.
Publicado: (2022)

S100A16-induced adipogenesis is associated with up-regulation of 11 β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)
por: Zhang, Rihua, et al.
Publicado: (2019)

Hypothalamic-Pituitary-Adrenal Axis Abnormalities in Response to Deletion of 11β-HSD1 is Strain-Dependent
por: Carter, R N, et al.
Publicado: (2009)

PEDF Expression Is Inhibited by Insulin Treatment in Adipose Tissue via Suppressing 11β-HSD1
por: Zhou, Yinli, et al.
Publicado: (2013)

Cellular and genetic models of H6PDH and 11β‐HSD1 function in skeletal muscle
por: Zielinska, Agnieszka E., et al.
Publicado: (2017)

Inhibitory Effects of Prunella vulgaris L. Extract on 11β-HSD1 in Human Skin Cells
por: Roh, Kyung-Baeg, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_4a0qvrjlba5i09gvoploacrasp