Host-Primed Ebola Virus GP Exposes a Hydrophobic NPC1 Receptor-Binding Pocket, Revealing a Target for Broadly Neutralizing Antibodies

The filovirus surface glycoprotein (GP) mediates viral entry into host cells. Following viral internalization into endosomes, GP is cleaved by host cysteine proteases to expose a receptor-binding site (RBS) that is otherwise hidden from immune surveillance. Here, we present the crystal structure of...

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Detalles Bibliográficos
Autores principales: Bornholdt, Zachary A., Ndungo, Esther, Fusco, Marnie L., Bale, Shridhar, Flyak, Andrew I., Crowe, James E., Chandran, Kartik, Saphire, Erica Ollmann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Microbiology 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791852/
https://www.ncbi.nlm.nih.gov/pubmed/26908579
http://dx.doi.org/10.1128/mBio.02154-15

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791852/
https://www.ncbi.nlm.nih.gov/pubmed/26908579
http://dx.doi.org/10.1128/mBio.02154-15

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