Minicircle DNA Provides Enhanced and Prolonged Transgene Expression Following Airway Gene Transfer

Gene therapy for cystic fibrosis using non-viral, plasmid-based formulations has been the subject of intensive research for over two decades but a clinically viable product has yet to materialise in large part due to inefficient transgene expression. Minicircle DNA give enhanced and more persistent...

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Detalles Bibliográficos
Autores principales: Munye, Mustafa M., Tagalakis, Aristides D., Barnes, Josephine L., Brown, Rachel E., McAnulty, Robin J., Howe, Steven J., Hart, Stephen L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792149/
https://www.ncbi.nlm.nih.gov/pubmed/26975732
http://dx.doi.org/10.1038/srep23125

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