Does inactivation of USP14 enhance degradation of proteasomal substrates that are associated with neurodegenerative diseases?

A common pathological hallmark of age-related neurodegenerative diseases is the intracellular accumulation of protein aggregates such as α-synuclein in Parkinson’s disease, TDP-43 in ALS, and tau in Alzheimer’s disease. Enhancing intracellular clearance of aggregation-prone proteins is a plausible s...

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Detalles Bibliográficos
Autores principales: Ortuno, Daniel, Carlisle, Holly J., Miller, Silke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000Research 2016
Materias:
Research Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792207/
https://www.ncbi.nlm.nih.gov/pubmed/26998235
http://dx.doi.org/10.12688/f1000research.7800.2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792207/
https://www.ncbi.nlm.nih.gov/pubmed/26998235
http://dx.doi.org/10.12688/f1000research.7800.2

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