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Does inactivation of USP14 enhance degradation of proteasomal substrates that are associated with neurodegenerative diseases?
A common pathological hallmark of age-related neurodegenerative diseases is the intracellular accumulation of protein aggregates such as α-synuclein in Parkinson’s disease, TDP-43 in ALS, and tau in Alzheimer’s disease. Enhancing intracellular clearance of aggregation-prone proteins is a plausible s...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
F1000Research
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792207/ https://www.ncbi.nlm.nih.gov/pubmed/26998235 http://dx.doi.org/10.12688/f1000research.7800.2 |