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The RyR2-P2328S mutation downregulates Na(v)1.5 producing arrhythmic substrate in murine ventricles
Catecholaminergic polymorphic ventricular tachycardia (CPVT) predisposes to ventricular arrhythmia due to altered Ca(2+) homeostasis and can arise from ryanodine receptor (RyR2) mutations including RyR2-P2328S. Previous reports established that homozygotic murine RyR2-P2328S (RyR2(S/S)) hearts show...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792352/ https://www.ncbi.nlm.nih.gov/pubmed/26545784 http://dx.doi.org/10.1007/s00424-015-1750-0 |