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The RyR2-P2328S mutation downregulates Na(v)1.5 producing arrhythmic substrate in murine ventricles

Catecholaminergic polymorphic ventricular tachycardia (CPVT) predisposes to ventricular arrhythmia due to altered Ca(2+) homeostasis and can arise from ryanodine receptor (RyR2) mutations including RyR2-P2328S. Previous reports established that homozygotic murine RyR2-P2328S (RyR2(S/S)) hearts show...

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Detalles Bibliográficos
Autores principales:	Ning, Feifei, Luo, Ling, Ahmad, Shiraz, Valli, Haseeb, Jeevaratnam, Kamalan, Wang, Tingzhong, Guzadhur, Laila, Yang, Dandan, Fraser, James A., Huang, Christopher L.-H., Ma, Aiqun, Salvage, Samantha C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2015
Materias:	Molecular and Cellular Mechanisms of Disease
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792352/ https://www.ncbi.nlm.nih.gov/pubmed/26545784 http://dx.doi.org/10.1007/s00424-015-1750-0

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