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Anoctamin 1 (Ano1) is required for glucose-induced membrane potential oscillations and insulin secretion by murine β-cells
Anions such as Cl(−) and HCO(3)(−) are well known to play an important role in glucose-stimulated insulin secretion (GSIS). In this study, we demonstrate that glucose-induced Cl(−) efflux from β-cells is mediated by the Ca(2+)-activated Cl(−) channel anoctamin 1 (Ano1). Ano1 expression in rat β-cell...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792454/ https://www.ncbi.nlm.nih.gov/pubmed/26582426 http://dx.doi.org/10.1007/s00424-015-1758-5 |