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Anoctamin 1 (Ano1) is required for glucose-induced membrane potential oscillations and insulin secretion by murine β-cells

Anions such as Cl(−) and HCO(3)(−) are well known to play an important role in glucose-stimulated insulin secretion (GSIS). In this study, we demonstrate that glucose-induced Cl(−) efflux from β-cells is mediated by the Ca(2+)-activated Cl(−) channel anoctamin 1 (Ano1). Ano1 expression in rat β-cell...

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Detalles Bibliográficos
Autores principales:	Crutzen, Raphaël, Virreira, Myrna, Markadieu, Nicolas, Shlyonsky, Vadim, Sener, Abdullah, Malaisse, Willy J., Beauwens, Renaud, Boom, Alain, Golstein, Philippe E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2015
Materias:	Ion Channels, Receptors and Transporters
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792454/ https://www.ncbi.nlm.nih.gov/pubmed/26582426 http://dx.doi.org/10.1007/s00424-015-1758-5

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