Cytokine secretion and NK cell activity in human ADAM17 deficiency

Genetic deficiencies provide insights into gene function in humans. Here we describe a patient with a very rare genetic deficiency of ADAM17. We show that the patient's PBMCs had impaired cytokine secretion in response to LPS stimulation, correlating with the clinical picture of severe bacterem...

Descripción completa

Detalles Bibliográficos
Autores principales: Tsukerman, Pinchas, Eisenstein, Eli M., Chavkin, Maor, Schmiedel, Dominik, Wong, Eitan, Werner, Marion, Yaacov, Barak, Averbuch, Diana, Molho-Pessach, Vered, Stepensky, Polina, Kaynan, Noa, Bar-On, Yotam, Seidel, Einat, Yamin, Rachel, Sagi, Irit, Elpeleg, Orly, Mandelboim, Ofer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper: Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792548/
https://www.ncbi.nlm.nih.gov/pubmed/26683521

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792548/
https://www.ncbi.nlm.nih.gov/pubmed/26683521

Ejemplares similares