Expression profiling reveals transcriptional regulation by Fbxw7/mTOR pathway in radiation-induced mouse thymic lymphomas

The tumor suppressor gene FBXW7 is deleted and mutated in many different types of human cancers. FBXW7 primarily exerts its tumor suppressor activity by ubiquitinating different oncoproteins including mTOR. Here we used gene transcript profiling to gain a deeper understanding of the role of FBXW7 in...

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Detalles Bibliográficos
Autores principales: Snijders, Antoine M., Liu, Yueyong, Su, Li, Huang, Yurong, Mao, Jian-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792592/
https://www.ncbi.nlm.nih.gov/pubmed/26575021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792592/
https://www.ncbi.nlm.nih.gov/pubmed/26575021

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