A Phase I Protocol of Hydralazine and Valproic Acid in Advanced, Previously Treated Solid Cancers

Smokers experience aberrant gene promoter methylation in their bronchial cells, which may predispose to the development of neoplasia. Hydralazine is a DNA demethylating agent, and valproic acid is a histone deacetylase inhibitor, and both have modest but synergistic anticancer activity in vitro. We...

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Detalles Bibliográficos
Autores principales: Bauman, Julie, Shaheen, Monte, Verschraegen, Claire F., Belinsky, Steven A., Houman Fekrazad, M., Lee, Fa-Chyi, Rabinowitz, Ian, Ravindranathan, Meera, Jones, Dennie V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792814/
https://www.ncbi.nlm.nih.gov/pubmed/24746712
http://dx.doi.org/10.1016/j.tranon.2014.03.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792814/
https://www.ncbi.nlm.nih.gov/pubmed/24746712
http://dx.doi.org/10.1016/j.tranon.2014.03.001

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