Cargando…

A Phase I Protocol of Hydralazine and Valproic Acid in Advanced, Previously Treated Solid Cancers

Smokers experience aberrant gene promoter methylation in their bronchial cells, which may predispose to the development of neoplasia. Hydralazine is a DNA demethylating agent, and valproic acid is a histone deacetylase inhibitor, and both have modest but synergistic anticancer activity in vitro. We...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bauman, Julie, Shaheen, Monte, Verschraegen, Claire F., Belinsky, Steven A., Houman Fekrazad, M., Lee, Fa-Chyi, Rabinowitz, Ian, Ravindranathan, Meera, Jones, Dennie V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Neoplasia Press 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792814/ https://www.ncbi.nlm.nih.gov/pubmed/24746712 http://dx.doi.org/10.1016/j.tranon.2014.03.001

Ejemplares similares

Antimetastatic effect of epigenetic drugs, hydralazine and valproic acid, in Ras-transformed NIH 3T3 cells
por: Pérez-Cárdenas, Enrique, et al.
Publicado: (2018)

Epstein–Barr virus-associated inflammatory pseudotumor of the spleen: report of two cases and review of the literature
por: Rosenbaum, Lizabeth, et al.
Publicado: (2009)

Antineoplastic effects of the DNA methylation inhibitor hydralazine and the histone deacetylase inhibitor valproic acid in cancer cell lines
por: Chavez-Blanco, Alma, et al.
Publicado: (2006)

Antimetastatic Effect of Epigenetic Drugs, Hydralazine and Valproic Acid, in Ras-Transformed NIH 3T3 Cells [Corrigendum]
Publicado: (2022)

Phase II Trial of Sorafenib in Combination with Capecitabine in Patients with Hepatocellular Carcinoma: INST 08‐20
por: Patt, Yehuda, et al.
Publicado: (2017)

Reversal of increased mammary tumorigenesis by valproic acid and hydralazine in offspring of dams fed high fat diet during pregnancy
por: Andrade, F. de Oliveira, et al.
Publicado: (2019)

Anaplastic Large Cell Lymphoma Associated With Breast Implants
por: Ravi-Kumar, Shalini, et al.
Publicado: (2012)

Hydralazine-Induced Vasculitis
por: Gandhi, Pulkit, et al.
Publicado: (2023)

Hydralazine-associated adverse events: a report of two cases of hydralazine-induced ANCA vasculitis
por: Zuckerman, Roman, et al.
Publicado: (2018)

Hydralazine-Induced Vasculitis With Gastrointestinal Pseudomelanosis
por: Novikov, Aleksey, et al.
Publicado: (2014)

Clinical Characteristics of Hydralazine-induced Lupus
por: Timlin, Homa, et al.
Publicado: (2019)

Hydralazine-Induced Isolated Lupus Nephritis
por: Khan, Naseer, et al.
Publicado: (2020)

Hydralazine-Associated Vasculitis and Pulmonary Hemorrhage
por: Strubchevska, Kateryna, et al.
Publicado: (2023)

Up-regulation of HLA class I antigen expression and antigen-specific CTL response in cervical cancer cells by the demethylating hydralazine and the histone deacetylase inhibitor valproic acid
por: Mora-García, María de Lourdes, et al.
Publicado: (2007)

Sorafenib-Induced Grade Four Hepatotoxicity in a Patient with Recurrent Gastrointestinal Stromal Tumor (GIST): A Case Report and Review of Literature
por: Murad, Waheed, et al.
Publicado: (2014)

Hydralazine target: From blood vessels to the epigenome
por: Arce, Claudia, et al.
Publicado: (2006)

Influence of hydralazine on the pharmacokinetics of tauromustine (TCNU) in mice.
por: Bibby, M. C., et al.
Publicado: (1992)

Anti-neoplastic properties of hydralazine in prostate cancer
por: Graça, Inês, et al.
Publicado: (2014)

ANA-Negative Hydralazine-Induced Pericardial Effusion
por: Zeitjian, Vicken, et al.
Publicado: (2017)

Hydralazine-induced vasculitis presenting with ocular manifestations
por: Hawn, Vivian S., et al.
Publicado: (2022)

Up-regulation of HLA class-I antigen expression and antigen-specific CTL response in cervical cancer cells by the demethylating agent hydralazine and the histone deacetylase inhibitor valproic acid
por: Mora-García, María de Lourdes, et al.
Publicado: (2006)

Response to Hydralazine-Valproate in a Patient with Mycosis Fungoides
por: Dueñas-Gonzalez, Alfonso, et al.
Publicado: (2010)

The mechanism of hydralazine-induced collagen biosynthesis in cultured fibroblasts
por: Karna, Ewa, et al.
Publicado: (2013)

Anti-TNF-α and hydralazine drug-induced lupus
por: Quaresma, Maria Victória, et al.
Publicado: (2015)

Comparison of Hydralazine and Labetalol to lower severe hypertension in pregnancy
por: Khan, Ayesha, et al.
Publicado: (2017)

Acute Low-Dose Hydralazine-Induced Lupus Pneumonitis
por: Holman, Sarah K., et al.
Publicado: (2017)

Hydralazine and Enzalutamide: Synergistic Partners against Prostate Cancer
por: Lopes, Nair, et al.
Publicado: (2021)

Hydralazine augmented ultrasound hyperthermia for the treatment of hepatocellular carcinoma
por: Karmacharya, Mrigendra B., et al.
Publicado: (2021)

The Utility of Bronchoscopy in Hydralazine-Induced ANCA-Associated Vasculitis
por: Khosla, Atulya Aman, et al.
Publicado: (2023)

A phase II study of epigenetic therapy with hydralazine and magnesium valproate to overcome chemotherapy resistance in refractory solid tumors
por: Candelaria, Myrna, et al.
Publicado: (2007)

Potentiation of the anti-tumour effect of melphalan by the vasoactive agent, hydralazine.
por: Stratford, I. J., et al.
Publicado: (1988)

Enhancement of chemotherapy and nitroimidazole-induced chemopotentiation by the vasoactive agent hydralazine.
por: Siemann, D. W.
Publicado: (1990)

The influence of hydralazine on the vasculature, blood perfusion and chemosensitivity of MAC tumours.
por: Quinn, P. K., et al.
Publicado: (1992)

Hydralazine and nitrates in the treatment of heart failure with reduced ejection fraction
por: Al‐Mohammad, Abdallah
Publicado: (2019)

Hydralazine-Induced Lupus Syndrome Manifesting as Large Pericardial Effusion
por: Wilson, Nathaniel R, et al.
Publicado: (2020)

Hydralazine-Induced Lupus Presenting With Pancytopenia: A Case Report
por: Brar, Yudhveer, et al.
Publicado: (2022)

The Effects of Verapamil, Hydralazine, and Doxazosin on Renin, Aldosterone, and the Ratio Thereof
por: Veldhuizen, Gregory P., et al.
Publicado: (2021)

A Rare Case of Hydralazine-Induced Diffuse Alveolar Hemorrhage
por: Xue, Angela, et al.
Publicado: (2023)

Isosorbide dinitrate-hydralazine combination therapy in African Americans with heart failure
por: Echols, Melvin R, et al.
Publicado: (2006)

Hydralazine-associated antineutrophil cytoplasmic antibody vasculitis with pulmonary–renal syndrome
por: Aeddula, Narothama Reddy, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_gh69e1l8r098407vgmlvhfnbeg