Depurinating estrogen-DNA adducts, generators of cancer initiation: their minimization leads to cancer prevention

Estrogens can initiate cancer by reacting with DNA. Specific metabolites of endogenous estrogens, the catechol estrogen-3,4-quinones, react with DNA to form depurinating estrogen-DNA adducts. Loss of these adducts leaves apurinic sites in the DNA, generating mutations that can lead to the initiation...

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Detalles Bibliográficos
Autores principales: Cavalieri, Ercole L., Rogan, Eleanor G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792821/
https://www.ncbi.nlm.nih.gov/pubmed/26979321
http://dx.doi.org/10.1186/s40169-016-0088-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792821/
https://www.ncbi.nlm.nih.gov/pubmed/26979321
http://dx.doi.org/10.1186/s40169-016-0088-3

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