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Depurinating estrogen-DNA adducts, generators of cancer initiation: their minimization leads to cancer prevention
Estrogens can initiate cancer by reacting with DNA. Specific metabolites of endogenous estrogens, the catechol estrogen-3,4-quinones, react with DNA to form depurinating estrogen-DNA adducts. Loss of these adducts leaves apurinic sites in the DNA, generating mutations that can lead to the initiation...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Springer Berlin Heidelberg
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792821/ https://www.ncbi.nlm.nih.gov/pubmed/26979321 http://dx.doi.org/10.1186/s40169-016-0088-3 |