Promotion of mitochondrial biogenesis by necdin protects neurons against mitochondrial insults

Neurons rely heavily on mitochondria for their function and survival. Mitochondrial dysfunction contributes to the pathogenesis of neurodegenerative diseases such as Parkinson's disease. PGC-1α is a master regulator of mitochondrial biogenesis and function. Here we identify necdin as a potent P...

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Detalles Bibliográficos
Autores principales: Hasegawa, Koichi, Yasuda, Toru, Shiraishi, Chinatsu, Fujiwara, Kazushiro, Przedborski, Serge, Mochizuki, Hideki, Yoshikawa, Kazuaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4793078/
https://www.ncbi.nlm.nih.gov/pubmed/26971449
http://dx.doi.org/10.1038/ncomms10943

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4793078/
https://www.ncbi.nlm.nih.gov/pubmed/26971449
http://dx.doi.org/10.1038/ncomms10943

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