Dysregulation of Nutrient Sensing and CLEARance in Presenilin Deficiency

Attenuated auto-lysosomal system has been associated with Alzheimer disease (AD), yet all underlying molecular mechanisms leading to this impairment are unknown. We show that the amino acid sensing of mechanistic target of rapamycin complex 1 (mTORC1) is dysregulated in cells deficient in presenilin...

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Detalles Bibliográficos
Autores principales: Reddy, Kavya, Cusack, Corey L., Nnah, Israel C., Khayati, Khoosheh, Saqcena, Chaitali, Huynh, Tuong B., Noggle, Scott A., Ballabio, Andrea, Dobrowolski, Radek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4793148/
https://www.ncbi.nlm.nih.gov/pubmed/26923592
http://dx.doi.org/10.1016/j.celrep.2016.02.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4793148/
https://www.ncbi.nlm.nih.gov/pubmed/26923592
http://dx.doi.org/10.1016/j.celrep.2016.02.006

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