Simultaneous determination of 8-oxo-2’-deoxyguanosine and 8-oxo-2’-deoxyadenosine in human retinal DNA by liquid chromatography nanoelectrospray-tandem mass spectrometry

Age-related macular degeneration (AMD) is the leading cause of blindness among older adults in the developed world. Oxidative damage to mitochondrial DNA (mtDNA) in the retinal pigment epithelium (RPE) may play a key role in AMD. Measurement of oxidative DNA lesions such as 8-oxo-2’-deoxyguanosine (...

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Detalles Bibliográficos
Autores principales: Ma, Bin, Jing, Meng, Villalta, Peter W., Kapphahn, Rebecca J., Montezuma, Sandra R., Ferrington, Deborah A., Stepanov, Irina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4793187/
https://www.ncbi.nlm.nih.gov/pubmed/26979577
http://dx.doi.org/10.1038/srep22375

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4793187/
https://www.ncbi.nlm.nih.gov/pubmed/26979577
http://dx.doi.org/10.1038/srep22375

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