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CYP1B1 Enhances Cell Proliferation and Metastasis through Induction of EMT and Activation of Wnt/β-Catenin Signaling via Sp1 Upregulation

Cytochrome P450 1B1 (CYP1B1) is a major E(2) hydroxylase involved in the metabolism of potential carcinogens. CYP1B1 expression has been reported to be higher in tumors compared to normal tissues, especially in hormone-related cancers including breast, ovary, and prostate tumors. To explore the role...

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Detalles Bibliográficos
Autores principales: Kwon, Yeo-Jung, Baek, Hyoung-Seok, Ye, Dong-Jin, Shin, Sangyun, Kim, Donghak, Chun, Young-Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794175/
https://www.ncbi.nlm.nih.gov/pubmed/26981862
http://dx.doi.org/10.1371/journal.pone.0151598