Diaryl Disulfides as Novel Stabilizers of Tumor Suppressor Pdcd4

The translation inhibitor and tumor suppressor Pdcd4 was reported to be lost in various tumors and put forward as prognostic marker in tumorigenesis. Decreased Pdcd4 protein stability due to PI3K-mTOR-p70(S6K1) dependent phosphorylation of Pdcd4 followed by β-TrCP1-mediated ubiquitination, and prote...

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Detalles Bibliográficos
Autores principales: Schmid, Tobias, Blees, Johanna S., Bajer, Magdalena M., Wild, Janine, Pescatori, Luca, Cuzzucoli Crucitti, Giuliana, Scipione, Luigi, Costi, Roberta, Henrich, Curtis J., Brüne, Bernhard, Colburn, Nancy H., Di Santo, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794182/
https://www.ncbi.nlm.nih.gov/pubmed/26982744
http://dx.doi.org/10.1371/journal.pone.0151643

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794182/
https://www.ncbi.nlm.nih.gov/pubmed/26982744
http://dx.doi.org/10.1371/journal.pone.0151643

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