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Diaryl Disulfides as Novel Stabilizers of Tumor Suppressor Pdcd4
The translation inhibitor and tumor suppressor Pdcd4 was reported to be lost in various tumors and put forward as prognostic marker in tumorigenesis. Decreased Pdcd4 protein stability due to PI3K-mTOR-p70(S6K1) dependent phosphorylation of Pdcd4 followed by β-TrCP1-mediated ubiquitination, and prote...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794182/ https://www.ncbi.nlm.nih.gov/pubmed/26982744 http://dx.doi.org/10.1371/journal.pone.0151643 |