The MDM2 small-molecule inhibitor RG7388 leads to potent tumor inhibition in p53 wild-type neuroblastoma

Neuroblastoma is an aggressive pediatric malignancy which is >98% p53 wild-type at diagnosis. As a primary repressor of p53 activity and part of a p53-activated negative feedback loop, targeting of mouse double minute 2 homolog (MDM2) is an attractive therapeutic approach to reactivation of p53....

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Detalles Bibliográficos
Autores principales: Lakoma, A, Barbieri, E, Agarwal, S, Jackson, J, Chen, Z, Kim, Y, McVay, M, Shohet, J M, Kim, E S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794278/
https://www.ncbi.nlm.nih.gov/pubmed/26998348
http://dx.doi.org/10.1038/cddiscovery.2015.26

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794278/
https://www.ncbi.nlm.nih.gov/pubmed/26998348
http://dx.doi.org/10.1038/cddiscovery.2015.26

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