Optogenetic Silencing of Na(v)1.8-Positive Afferents Alleviates Inflammatory and Neuropathic Pain123

We report a novel transgenic mouse model in which the terminals of peripheral nociceptors can be silenced optogenetically with high spatiotemporal precision, leading to the alleviation of inflammatory and neuropathic pain. Inhibitory archaerhodopsin-3 (Arch) proton pumps were delivered to Na(v)1.8(+...

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Detalles Bibliográficos
Autores principales: Daou, Ihab, Beaudry, Hélène, Ase, Ariel R., Wieskopf, Jeffrey S., Ribeiro-da-Silva, Alfredo, Mogil, Jeffrey S., Séguéla, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2016
Materias:
New Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794527/
https://www.ncbi.nlm.nih.gov/pubmed/27022626
http://dx.doi.org/10.1523/ENEURO.0140-15.2016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794527/
https://www.ncbi.nlm.nih.gov/pubmed/27022626
http://dx.doi.org/10.1523/ENEURO.0140-15.2016

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