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Optogenetic Silencing of Na(v)1.8-Positive Afferents Alleviates Inflammatory and Neuropathic Pain123

We report a novel transgenic mouse model in which the terminals of peripheral nociceptors can be silenced optogenetically with high spatiotemporal precision, leading to the alleviation of inflammatory and neuropathic pain. Inhibitory archaerhodopsin-3 (Arch) proton pumps were delivered to Na(v)1.8(+...

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Detalles Bibliográficos
Autores principales:	Daou, Ihab, Beaudry, Hélène, Ase, Ariel R., Wieskopf, Jeffrey S., Ribeiro-da-Silva, Alfredo, Mogil, Jeffrey S., Séguéla, Philippe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Society for Neuroscience 2016
Materias:	New Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794527/ https://www.ncbi.nlm.nih.gov/pubmed/27022626 http://dx.doi.org/10.1523/ENEURO.0140-15.2016

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