Substitution of Heavy Complementarity Determining Region 3 (CDR-H3) Residues Can Synergistically Enhance Functional Activity of Antibody and Its Binding Affinity to HER2 Antigen

To generate a biobetter that has improved therapeutic activity, we constructed scFv libraries via random mutagenesis of several residues of CDR-H3 and -L3 of hu4D5. The scFv clones were isolated from the phage display libraries by stringent panning, and their anti-proliferative activity against HER2...

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Detalles Bibliográficos
Autores principales: Moon, Seung Kee, Park, So Ra, Park, Ami, Oh, Hyun Mi, Shin, Hyun Jung, Jeon, Eun Ju, Kim, Seiwhan, Park, Hyun June, Yeon, Young Joo, Yoo, Young Je
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Molecular and Cellular Biology 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794604/
https://www.ncbi.nlm.nih.gov/pubmed/26743905
http://dx.doi.org/10.14348/molcells.2016.2235

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794604/
https://www.ncbi.nlm.nih.gov/pubmed/26743905
http://dx.doi.org/10.14348/molcells.2016.2235

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