Associations of functional alanine-glyoxylate aminotransferase 2 gene variants with atrial fibrillation and ischemic stroke

Asymmetric and symmetric dimethylarginines (ADMA and SDMA) impair nitric oxide bioavailability and have been implicated in the pathogenesis of atrial fibrillation (AF). Alanine–glyoxylate aminotransferase 2 (AGXT2) is the only enzyme capable of metabolizing both of the dimethylarginines. We hypothes...

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Detalles Bibliográficos
Autores principales: Seppälä, Ilkka, Kleber, Marcus E., Bevan, Steve, Lyytikäinen, Leo-Pekka, Oksala, Niku, Hernesniemi, Jussi A., Mäkelä, Kari-Matti, Rothwell, Peter M., Sudlow, Cathie, Dichgans, Martin, Mononen, Nina, Vlachopoulou, Efthymia, Sinisalo, Juha, Delgado, Graciela E., Laaksonen, Reijo, Koskinen, Tuomas, Scharnagl, Hubert, Kähönen, Mika, Markus, Hugh S., März, Winfried, Lehtimäki, Terho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794714/
https://www.ncbi.nlm.nih.gov/pubmed/26984639
http://dx.doi.org/10.1038/srep23207

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794714/
https://www.ncbi.nlm.nih.gov/pubmed/26984639
http://dx.doi.org/10.1038/srep23207

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