RepA-WH1, the agent of an amyloid proteinopathy in bacteria, builds oligomeric pores through lipid vesicles

RepA-WH1 is a disease-unrelated protein that recapitulates in bacteria key aspects of human amyloid proteinopathies: i) It undergoes ligand-promoted amyloidogenesis in vitro; ii) its aggregates are able to seed/template amyloidosis on soluble protein molecules; iii) its conformation is modulated by...

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Detalles Bibliográficos
Autores principales: Fernández, Cristina, Núñez-Ramírez, Rafael, Jiménez, Mercedes, Rivas, Germán, Giraldo, Rafael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794723/
https://www.ncbi.nlm.nih.gov/pubmed/26984374
http://dx.doi.org/10.1038/srep23144

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794723/
https://www.ncbi.nlm.nih.gov/pubmed/26984374
http://dx.doi.org/10.1038/srep23144

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