CNS accumulation of regulatory B cells is VLA-4-dependent

OBJECTIVE: To investigate the role of very late antigen-4 (VLA-4) on regulatory B cells (Breg) in CNS autoimmune disease. METHODS: Experimental autoimmune encephalomyelitis (EAE) was induced in mice selectively deficient for VLA-4 on B cells (CD19cre/α4(f/f)) by immunization with myelin oligodendroc...

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Detalles Bibliográficos
Autores principales: Lehmann-Horn, Klaus, Sagan, Sharon A., Winger, Ryan C., Spencer, Collin M., Bernard, Claude C.A., Sobel, Raymond A., Zamvil, Scott S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794810/
https://www.ncbi.nlm.nih.gov/pubmed/27027096
http://dx.doi.org/10.1212/NXI.0000000000000212

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794810/
https://www.ncbi.nlm.nih.gov/pubmed/27027096
http://dx.doi.org/10.1212/NXI.0000000000000212

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