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CNS accumulation of regulatory B cells is VLA-4-dependent

OBJECTIVE: To investigate the role of very late antigen-4 (VLA-4) on regulatory B cells (Breg) in CNS autoimmune disease. METHODS: Experimental autoimmune encephalomyelitis (EAE) was induced in mice selectively deficient for VLA-4 on B cells (CD19cre/α4(f/f)) by immunization with myelin oligodendroc...

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Detalles Bibliográficos
Autores principales:	Lehmann-Horn, Klaus, Sagan, Sharon A., Winger, Ryan C., Spencer, Collin M., Bernard, Claude C.A., Sobel, Raymond A., Zamvil, Scott S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794810/ https://www.ncbi.nlm.nih.gov/pubmed/27027096 http://dx.doi.org/10.1212/NXI.0000000000000212

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