Cargando…
A MYLK variant regulates asthmatic inflammation via alterations in mRNA secondary structure
Myosin light-chain kinase (MYLK) is a gene known to be significantly associated with severe asthma in African Americans. Here we further examine the molecular function of a single-nucleotide polymorphism (SNP), located in the non-muscle myosin light-chain kinase isoform (nmMLCK), in asthma susceptib...
Autores principales: | Wang, Ting, Zhou, Tong, Saadat, Laleh, Garcia, Joe GN |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4795064/ https://www.ncbi.nlm.nih.gov/pubmed/25271083 http://dx.doi.org/10.1038/ejhg.2014.201 |
Ejemplares similares
-
Myosin light chain kinase (MYLK) coding polymorphisms modulate human lung endothelial cell barrier responses via altered tyrosine phosphorylation, spatial localization, and lamellipodial protrusions
por: Wang, Ting, et al.
Publicado: (2018) -
ROCK2 and MYLK variants and high-altitude pulmonary edema
por: Sikri, Gaurav, et al.
Publicado: (2016) -
Heterozygous Mylk3 Knockout Mice Partially Recapitulate Human DCM With Heterozygous MYLK3 Mutations
por: Tougas, Carson L., et al.
Publicado: (2019) -
A novel variant in MYLK causes thoracic aortic dissections: genotypic and phenotypic description
por: Hannuksela, Matias, et al.
Publicado: (2016) -
MYLK Mutations: Aortic Disease Presentation, Pregnancy Risk, and Characterization of Pathogenic Missense Variants
por: Wallace, Stephanie E., et al.
Publicado: (2018)