Design of a MCoTI-Based Cyclotide with Angiotensin (1-7)-Like Activity

We report for the first time the design and synthesis of a novel cyclotide able to activate the unique receptor of angiotensin (1-7) (AT1-7), the MAS1 receptor. This was accomplished by grafting an AT1-7 peptide analog onto loop 6 of cyclotide MCoTI-I using isopeptide bonds to preserve the α-amino a...

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Detalles Bibliográficos
Autores principales: Aboye, Teshome, Meeks, Christopher J., Majumder, Subhabrata, Shekhtman, Alexander, Rodgers, Kathleen, Camarero, Julio A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4795166/
https://www.ncbi.nlm.nih.gov/pubmed/26821010
http://dx.doi.org/10.3390/molecules21020152

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4795166/
https://www.ncbi.nlm.nih.gov/pubmed/26821010
http://dx.doi.org/10.3390/molecules21020152

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