Accurate and predictive antibody repertoire profiling by molecular amplification fingerprinting

High-throughput antibody repertoire sequencing (Ig-seq) provides quantitative molecular information on humoral immunity. However, Ig-seq is compromised by biases and errors introduced during library preparation and sequencing. By using synthetic antibody spike-in genes, we determined that primer bia...

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Detalles Bibliográficos
Autores principales: Khan, Tarik A., Friedensohn, Simon, de Vries, Arthur R. Gorter, Straszewski, Jakub, Ruscheweyh, Hans-Joachim, Reddy, Sai T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4795664/
https://www.ncbi.nlm.nih.gov/pubmed/26998518
http://dx.doi.org/10.1126/sciadv.1501371

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4795664/
https://www.ncbi.nlm.nih.gov/pubmed/26998518
http://dx.doi.org/10.1126/sciadv.1501371

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