Charge Variants of an Avastin Biosimilar Isolation, Characterization, In Vitro Properties and Pharmacokinetics in Rat

The similarity between a proposed biosimilar product and the reference product can be affected by many factors. This study is designed to examine whether any subtle difference in the distribution of the charge variants of an Avastin biosimilar can affect its in vitro potency and in vivo PK. Here, th...

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Detalles Bibliográficos
Autores principales: Zhao, Yan-Yan, Wang, Ning, Liu, Wan-Hui, Tao, Wen-Jie, Liu, Li-Li, Shen, Zhen-Duo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4795741/
https://www.ncbi.nlm.nih.gov/pubmed/26987122
http://dx.doi.org/10.1371/journal.pone.0151874

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4795741/
https://www.ncbi.nlm.nih.gov/pubmed/26987122
http://dx.doi.org/10.1371/journal.pone.0151874

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