Systems Pharmacology and Rational Polypharmacy: Nitric Oxide−Cyclic GMP Signaling Pathway as an Illustrative Example and Derivation of the General Case

Impaired nitric oxide (NO˙)-cyclic guanosine 3', 5'-monophosphate (cGMP) signaling has been observed in many cardiovascular disorders, including heart failure and pulmonary arterial hypertension. There are several enzymatic determinants of cGMP levels in this pathway, including soluble gua...

Descripción completa

Detalles Bibliográficos
Autores principales: Garmaroudi, Farshid S., Handy, Diane E., Liu, Yang-Yu, Loscalzo, Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4795786/
https://www.ncbi.nlm.nih.gov/pubmed/26985825
http://dx.doi.org/10.1371/journal.pcbi.1004822

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4795786/
https://www.ncbi.nlm.nih.gov/pubmed/26985825
http://dx.doi.org/10.1371/journal.pcbi.1004822

Ejemplares similares