High end GPCR design: crafted ligand design and druggability analysis using protein structure, lipophilic hotspots and explicit water networks

PURPOSE: G Protein-Coupled Receptors (GPCRs) are a large family of therapeutically important proteins and as diverse X-ray structures become available it is increasingly possible to leverage structural information for rational drug design. We present herein approaches that use explicit water network...

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Detalles Bibliográficos
Autores principales: Mason, Jonathan S, Bortolato, Andrea, Weiss, Dahlia R, Deflorian, Francesca, Tehan, Benjamin, Marshall, Fiona H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4796210/
http://dx.doi.org/10.1186/2193-9616-1-23

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4796210/
http://dx.doi.org/10.1186/2193-9616-1-23

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