Biotherapeutic protein formulation variables influence protein integrity and can promote post-translational modifications as shown using chicken egg white lysozyme as a model system

OBJECTIVES: The effect of different formulations variables on protein integrity were investigated using lysozyme as a model protein for the development of biotherapeutic protein formulations for use in the clinic. RESULTS: Buffer composition/concentration was the key variable of formulation reagents...

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Detalles Bibliográficos
Autores principales: Gourbatsi, Evdoxia, Povey, Jane, Uddin, Shahid, Smales, C. Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2015
Materias:
Original Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4796366/
https://www.ncbi.nlm.nih.gov/pubmed/26699895
http://dx.doi.org/10.1007/s10529-015-2014-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4796366/
https://www.ncbi.nlm.nih.gov/pubmed/26699895
http://dx.doi.org/10.1007/s10529-015-2014-y

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