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Biotherapeutic protein formulation variables influence protein integrity and can promote post-translational modifications as shown using chicken egg white lysozyme as a model system
OBJECTIVES: The effect of different formulations variables on protein integrity were investigated using lysozyme as a model protein for the development of biotherapeutic protein formulations for use in the clinic. RESULTS: Buffer composition/concentration was the key variable of formulation reagents...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Netherlands
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4796366/ https://www.ncbi.nlm.nih.gov/pubmed/26699895 http://dx.doi.org/10.1007/s10529-015-2014-y |